KMID : 0361420120360010080
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Journal of Korean Academy of Rehabilitation Medicine 2012 Volume.36 No. 1 p.80 ~ p.87
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Effect of Ultra-marathon (308 km) Race on Bone Metabolism and Cartilage Damage Biomarkers
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Shin Kyung-A
Kim Al-Chan Kim Young-Joo Lee Yoon-Hee Shin Young-Oh Kim Sang-Hoon Park Young-Sik Nam Hee-Seung Kim Tai-Kon Kim Hyoung-Seop Park Yong-Bum
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Abstract
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Objective: To evaluate the potential eff ects of a 308-km ultra-marathon on bone and cartilage biomarkers.
Method: Venous blood samples were collected at pre-race, 100 km, 200 km, and 308 km checkpoints. Th e following markers of cartilage damage and bone metabolism were studied: osteocalcin (OC), osteoprotegerin (OPG), and calcium, phosphorous, and cartilage oligomeric matrix protein (COMP).
Results: Blood samples were taken from 20 male runners at four different checkpoints. Serum COMP was increased by 194.1% (130.7% at 100 km and 160.4% at 200 km). Serum OPG was signifi cantly increased by 158.57% at 100 km and 114.1% at 200 km compared to the pre-race measures. OC was transiently suppressed at 200 km. Serum calcium and phosphorous concentrations decreased compared to the pre-race measures.
Conclusion: This study showed that the 308-km ultra-marathon induced several changes, including transient uncoupling of bone metabolism, increased bone resorption, suppressed bone formation, and bone turnover and had a major impact on cartilage structure.
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KEYWORD
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Ultra-marathon, Osteoprotegerin, COMP, Osteocalcin
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